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Specification Of Chemical Structure And Mechanism of Cialis Action.

Cialis is a drug that manufactured by Eli Lilly Company in the 2003 year. It is the first medication for erectile dysfunction treatment that can act for 36 hours. Cialis is a probable mean for stimulation and excitement of erectile dysfunction (for patients with erectile dysfunction and other sexual disorders).

Drug’s Mechanism of Action

An erection during sexual stimulation is caused by increasing blood flow to the tissues of the penis. It happens due to the relaxation of smooth muscles in arteries of corpora cavernosa. This process is accompanied by the release of nitric oxide from endothelial cells in the corpus cavernosum.

Nitric oxide has a stimulatory effect on the synthesis of cGMP in the smooth muscle cells. The accumulation of cGMP leads to the muscle relaxation and increases blood flow to the cavernous bodies. Tadalafil (the inhibitor of PDE5) increase the amount of cGMP and enhance erectile function. But Tadalafil without sexual stimulation has no effect.

Studies in vitro have shown that Tadalafil is a selective inhibitor of PDE5. PDE5 is found in smooth muscles of the corpora cavernosa and in smooth muscles of vessels in internal organs, skeletal muscle, platelets, kidneys, lungs, pancreas, and cerebellum.In in vitro studies have found that the effect of Tadalafil is stronger on PDE5 than on other phosphodiesterases. Tadalafil is in 10 thousand times more potent for PDE5 than for FDE1, PDE2, PDE4, and FDE 7. Those enzymes are in the heart, brain, blood vessels, liver, leukocytes, skeletal muscles.

Cialis And Alcohol

Does Cialis can be taken with alcohol? Or maybe the patient is able to drink the drug with beer or wine? Cialis and alcohol can be used together, but only by adhering to certain rules.

Alcohol is a substance that has a powerful impact on the entire human organism. Alcohol in excessive quantity can cause severe intoxication. Will consider the efficacy and safety of the combination of a pharmacological drug Cialis and ethanol in alcohol.

Substances that are contained in each of the alcohol drinks can depress the activity of the nervous system. After the use of ethanol happens a significant reduction of the sensitivity. In this regard, the use of alcohol can lead to significant disturbances in genitals. The effect of combining drugs like Cialis with alcohol drinks can be very diverse. It can be represented by a simple classification:
firstly alcohol and Cialis give powerful force and energy, and as a consequence a strong sexual arousal;
a man is ready for a pretty long sexual contact;
then this combination makes a significant increasing of sexual arousal, all muscles in the relax;
the man does not receive the resistance for the possible erection.

Small doses of ethanol have practically no effect on the male reproductive system. But, at the moment when the dose increases, disturbances may occur immediately. Chemical components can impede blood circulation for a short period of time.

Pharmacological drug Cialis may be combined with small dosages of alcoholic beverages. But, there is a small correction, it is necessary to know that increasing of the dose can lead to unforeseen consequences.